3PO (b)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PFKFB3（6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶）抑制剂，减少糖酵解通量并抑制葡萄糖摄取。

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor, reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.3PO may be useful agents in combination with other drugs that inhibit Y cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of Y.

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Metabolic Enzyme/Protease

Glucokinase

PFKFB3

Other Indications

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13309-08-5

210.23

C13H10N2O

>98% (HPLC)

DMSO: > 10 mM

C1=CC(=CN=C1)/C=C/C(=O)C2=CC=NC=C2

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(-20℃)

With Ice Pack

≥ 2 years